From the T Station:

Take Orange Line - To Chinatown Station 
Walk a short distance East on Chinatown Station - Walkway.
Turn left on Essex St.
Walk approx. 1 block East on Essex St.
Turn right on Harrison Ave.
Walk approx. 1 block South on Harrison Ave.

I-93S / US-1 S. Take exit 20B-A toward I-90 West / Mass Pike / S. Station. Take Exit 20 A toward South Station. Turn right onto Kneeland Street heading into China Town/Theater District.  Turn right onto Hudson, or Tyler Street making a left onto Beach Street.  Stay on Beach Street. Make a left onto Harrison.   

From the South:

I-95N toward Boston. Merge onto I-93N / US-1 N via exit 12 toward Boston. Exit 20 toward I-90 / Logan Airport / Worcester / S. Station. Take Frontage Road exit on the Left toward South Station. Turn slight right onto New Frontage Road N / Frontage Rd / Frontage Rd Northbound. Take the Kneeland St. ramp. Take the ramp toward China Town staying on Kneeland Street.  Turn right onto Hudson, or Tyler Street making a left onto Beach Street. Stay on Beach Street. Make a left onto Harrison.  

From the West: